Publications

Pangeni R, Poudel S, Momin M, Farkas D, Dalton C, Hall F, Kang J, Hylemon P, Longest W, Hindle M, Xu Q*, Inhalable tobramycin EEG powder formulation for treating Pseudomonas aeruginosa-induced lung infection. International Journal of Pharmaceutics. 2024, 662, 124504.
Meng T, Zheng J, Shin C, Gao N, Bande D, Sudarjat H, Chow W, Halquist M, Yu F, Acharya G, Xu Q*, Combination nanomedicine strategy for preventing high-risk corneal transplantation rejection, ACS Nano, 2024, DOI: 10.1021/acsnano.4c06595.
Ingabire D, Qin C, Meng T, Raynold A, Sudarjat H, Townsend E, Pangeni R, Poudel S, Arriaga M, Zhao L, Chow W, Banks M*, Xu Q*, Nor-LAAM loaded PLGA microparticles for treating opioid use disorder. Journal of Controlled Release. 2024, 373, 93-104.
Poudel S, Kaffash E, Zhao L, Pangeni R, Chow W, Xu Q*. Dexamethasone sodium phosphate loaded nanoparticles for prevention of nitrogen mustard induced corneal injury. Experimental Eye Research. 2024, 243, 109902.
Muchhala K, Kang M, Koseli E, Poklis J, Xu Q, Dewey W, Fettweis J, Jimenez N, Akbarali H. The role of morphine-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis, FASEB Journal. 2024;38:e23603.

Meng T #, Sudarjat H, Momin M, Ma J, Xu Q. Development of uniform fenofibrate-loaded biodegradable microparticle by membrane emulsification, Int J Pharm. 2023, 10.1016/j.ijpharm.2023.123675.
Meng T #, Zheng J #, Chen M #, Zhao Y, Sudarjat H, Aji Alex M.R., Kulkarni V, Oh Y, Xia S, Ding Z, Han H, Anders N, Rudek M, Chow W, Stark W, Ensign L, Hanes J *, Xu Q*, Six-month effective treatment of corneal graft rejection, Science Advances, 2023, 9, 12, eadf4608. PMID: 36947612
Shah A, Park E, Luke T, Xu Q, Jewell A, Couser N, The Role of Genetic Testing in Avoiding Diagnostic Delays in Inherited Retinal Disease, Retinal Cases & Brief Reports, 2023, DOI: 10.1097/ICB.0000000000001436, PMID: 37116464
Zhang Y#, Li S#, Loch K#, Duncan G, Kaler L, Pangeni R, Peng W, Wang S*, Gong X*, Xu Q*, pH-responsive Mucus-penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue. ACS Macro Letters, 2023, 12, 446−453. PMID: 36951898
Pangeni R, Hassan A, Farkas D, Sudarjat H, Longest W, Hindle M, Xu Q*, New Air-Jet Dry Powder Insufflator for High-Efficiency Aerosol Delivery to Rats. Molecular Pharmaceutics, 2023, 20, 4, 2207-2216. PMID: 36938947
Pangeni R, Meng T, Poudel S, Sharma D, Hutsell H, Ma J, Rubin B, Longest W, Hindle M, Xu Q*, Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers. International Journal of Pharmaceutics, 2023, 634, 122661. PMID: 36736964

Linssen R, Chai G, Ma J, Kummarapurugu A, van Woensel J, Nem R, Kaler L, Duncan G, Zhou L, Rubin B, Xu Q #, Neutrophil Extracellular Traps increase airway mucus viscoelasticity and impede particle transit, American Journal of Respiratory Cell and Molecular Biology, 2020, DOI: 10.1165/rcmb.2020-0168OC.
Xia S, Ding Z, Luo L, Chen B, Schneider J, Yang J, Eberhart C,Stark W, Xu Q #, Shear-thinning viscous materials for subconjunctival injection of microparticles, AAPS PharmSciTech, 2020, DOI: 10.1208/s12249-020-01877-9
Xuan W, Moothedathu Raynold A, Meng T, Zheng J, Xu Q #, 3D engineering for optic neuropathy treatment, Drug Discovery Today, 2020, DOI: 10.1016/j.drudis.2020.09.034
Chai G, A Hanssan, T Meng, Lou L, Ma J, Simmers R, Rubin B, Zhou QT, Longest PW, Hindle M, Xu Q, Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery, Nanomedicine: Nanotechnology, Biology, and Medicine, DOI: 10.1016/j.nano.2020.102262
Yang J, Luo L, Oh Y, Meng T, Xia S, Emmert D, Wang B, Suarez M, Eberhart C, Lee S, Stark W, Ensign L, Hanes J, Xu Q, Sunitinib malate-loaded biodegradable microspheres for the prevention of corneal neovascularization in rats, Journal of Controlled Release, 2020, DOI: 10.1016/j.jconrel.2020.08.019

Zhu X, He W, Du Y, Kraus C, Xu Q, Sun T, Yu J, Lu Y, Presence of posterior staphyloma in congenital cataract children, Curr Eye Res, 2019, DOI: 10.1080/02713683.2019.1637437
Udupa S, Nguyen S, Hoang G, Nguyen T, Quinones A, Pham K, Asaka R, Nguyen K, Elgogary A, Jung J, Xu Q, Fu J, Thomas A, Tsukamoto T, Hanes J, Slusher B, Cooper A, Le A. Upregulation of the glutaminase II pathway contributes to glutamate production upon glutaminase 1 inhibition in pancreatic cancer, Proteomics, 2019, DOI: 10.1002/pmic.201800451
Meng T, Kulkarni V, Simmers R, Brar V, Xu Q#, The therapeutic implications of nanomedicine for ocular drug delivery, Drug Discovery Today, 2019, DOI: 10.1016/j.drudis.2019.05.006
Qiu F, Meng T, Chen Q, Zhou K, Shao Y, Matlock G, Ma X, Wu W, Du Y, Wang X, Deng G, Ma J #, Xu Q#, Fenofibrate-loaded biodegradable nanoparticles for the treatment of experimental diabetic retinopathy and neovascular age-related macular degeneration, Molecular Pharmaceutics, 2019, 16, 1958-1970
Wang B*, Tang Y*, Oh Y, Lamb N, Xia S, Ding Z, Chen B, Suarez M, Meng T, Kulkarni V, Eberhart C, Ensign L, Stark W, Hanes J, Xu Q#. Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization, Nanomedicine-NBM, 2019, 17, 119-123.
Luo L, Yang J, Oh Y, Hartsock M, Xia S, Kim Y, Ding Z, Meng T, Eberhart C, Ensign L, Thorne J, Stark W, Duh E, Xu Q#, Hanes J#, Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis, J Controlled Release, 2019, 296, 68-80.

C. Schneider*, Q. Xu*, N. Boylan*, J. Chisholm, B. Tang, B. Schuster, A. Henning, L. Ensign, E. Lee, P. Adstamonghonhul, B. Simons, X. Gong, S. Wang, T. Yu, M. Boyle, J. Suk, J. Hanes, Nanoparticles that do not adhere to mucus provide uniform and long- lasting drug delivery to airways following inhalation, Science Advances, 2017, 3(4): e1601556.
D. White, S. Sengupta, M. Saxena, Q. Xu, J. Hanes, D Ding, H. Ji, and J. Mumm. Innate immune system regulation of retinal regeneration – immunomodulatory enhancement of photoreceptor replacement kinetics in zebrafish, Proc Natl Acad Sci USA, 2017, DOI: 10.1073/pnas.1617721114
F. Kashiwabuchi, K. Parikh, R. Omiadze, S. Zhang, L. Luo, H. Patel, Q. Xu, L. Ensign, H. Mao, J. Hanes, P. McDonnell, Development of absorbable, antibiotic-eluting sutures for ophthalmic surgery, Transl Vis Sci Tech. 2017, 6(1): 1.

A. Elgogary*, Q. Xu*, B. Poore, J. Alt, S. Zimmermann, L. Zhao, J. Fu, B. Chen, S. Xia, Y. Liu, M. Neisser, C. Nguyen, R. Lee, J. Park, J. Reyes, T. Hartung, C. Rojas, R. Rais, T. Tsukamoto, G. Semenza#, J. Hanes#, B. Slusher#, A. Le#, Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer, Proc Natl Acad Sci USA, 2016, 113(36):E5328-5336.
K. Maisel, M. Reddy, Q. Xu, S. Chattopadhyay, R. Cone, L.M. Ensign, J. Hanes, Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo, Nanomedicine, 2016, 11(11), 1337- 1343
J. Suk, Q. Xu, N. Kim, J. Hanes, L. Ensign. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Advanced Drug Delivery Reviews. 2016, 99, Part A:28-51
Q. Xu, L. Ensign, N. L. Boylan, A. Schon, X. Gong, J. Yang, N. Lamb, S. Cai, T. Yu, E. Freire, J. Hanes, Impact of surface polyethylene glycol (PEG) density on biodegradable nanoparticle transport in mucus ex vivo and distribution in vivo. ACS Nano, 2015, 9(9), 9217-9227
T. Yu, K. Chan, A. Anonuevo, X. Song, B. Schuster, S. Chattopadhyay, N. Oskolkov, Q. Xu, H. Himat, L. Ensign, P. van Zjil, M. McMahon, J. Hanes, Liposomal mucuspenetrating particles (MPP) for efficient mucosal delivery and intravaginal diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI), Nanomedicine-NBM, 2015, 11(2), 401-405.
L. Yang, B.H. San, J. Kessler, J. H. Kim, Q. Xu, J. Hanes, S. M. Yu, Non-covalent photo-patterning of gelatin matrices using caged collagen mimetic peptides, Macromol Biosci, 2015, 15, 52-62 (front journal cover feature)
Q. Pan*, Q. Xu*, N.J. Boylan, N.W. Lamb, D. Emmert, J. Yang, L. Tang, C.G. Eberhart, J. Hanes, W.J. Stark, Corticosteroid-loaded biodegradable nanoparticles for pretention of corneal allograft rejection in rats, J Control Release, 2015, 201, 32-40
E. Nance, C. Zhang, T. Shih, Q. Xu, B. Schuster, J. Hanes, Brain-penetrating nanoparticles improve paclitaxel efficacy in malignant gliomas, ACS Nano, 2014, 8(10):10655-64
K. Fu, Q. Xu, J. Czernuszka, J. Triffitt, Z. Xia. Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation. Biomed Mater, 2013, 8, 056007 (featured as 2013 journal highlights).
Q. Xu, N. Boylan, B. Miao, S. Cai, H. Patel, J. Hanes, Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus, J Control Release, 2013, 170, 279-286
Q. Xu, N. Boylan, J. Suk, Y. Wang, E. Nance, J. Yang, P. McDonnell, R. Cone, E. Duh, J. Hanes, Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo, J Control Release, 2013,167, 76-84 (featured as cover story by the editor and journal’s front cover)
Q. Xu, S. Kambhampati, R. Kannan, Nanotechnology approaches for ocular drug delivery, Middle East Afr J Ophthalmol, 2013, 20, 26-37
E. Nance, G. Woodworth, K. Sailor, T. Shih, Q. Xu, G. Swaminathan, D. Xiang, C. Eberhart, J. Hanes, A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue, Sci Transl Med, 4 (2012) 149ra119 (featured as journal cover)
M. Matthaei, H. Meng, I. Bhutto, Q. Xu, E. Boelke, J. Hanes, A. Jun, Systematic assessment of microneedle injection into the mouse cornea, Eur J Med Res, 17 (2012) 19
K. Fu, Q. Xu, J. Czernuszka, C. McKenna, F. Ebetino, G. Russell, J. Triffitt, Z. Xia, Prolonged osteogenesis from human mesenchymal stem cells implanted in immunodeficient mice by using coralline hydroxyapatite incorporating rhBMP2 microspheres, J Biomed Mater Res A, 2010, 92A: 1256-1264
Q. Xu, A. Crossley, J. Czernuszka, Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres, J Pharm Sci, 2009, 98:2377-2389
Q. Xu, J. Czernuszka, Controlled release of amoxicillin from hydroxyapatite-coated poly(lactic-co-glycolic acid) microspheres, J Control Release, 2008, 127: 146-153
Q. Xu, J. Czernuszka, Drug delivery systems based on hydroxyapatite-coated poly(lactic-co-glycolic acid) microspheres, MRS Proceedings, 2008, Vol.1063-OO05-08
Q. Xu, Y. Tanaka, J. Czernuszka, Encapsulation and release of a hydrophobic drug from hydroxyapatite coated liposomes, Biomaterials, 2007, 28, 2687-2694

Xu Research Group

School of Pharmacy

Publications